Name：Kai Zhou

Position：Associate Professor

E-mail：[email protected]

Personal Statement:

Dr. Kai Zhou received his Ph.D. degree from KU Leuven in Belgium, and then joined University Medical Center Groningen in the Netherlands for postdoctoral training. In 2015, he joined Zhejiang University as an assistant professor, and then moved to Shenzhen People's Hospital in 2018. In 2024, Dr. Zhou joined the Medical School of Shenzhen University as an associate professor. He was awarded Shenzhen Overseas & local leading high-level talents. He also serves as an editorial board member/associate editor of Microbiology Spectrum, Frontiers in Medicine, Frontiers in Public Health, Infectious Microbes & Diseases, and Genes. His main research interests are mechanisms of antibiotic resistance and bacterial pathogenicity. He has published more than 90 high quality peer-reviewed papers.

Research Interests:

Antibiotic resistance mechanisms and pathogenesis of pathogens

Mechanisms of pathogen-host interactions 

Mechanisms of phage resistance and phage bactericidal mechanisms

Bacterial genome evolution

Research Projects:

1. NSFC, Molecular mechanism of morphological variation mediating the development of phage resistance in Klebsiella pneumoniae (grant no. 82172330), CNY 550,000, 01/01/2022-12/31/2025 (PI)

2. National Key R&D Program, Structure and function of key bacterial pathogenic factors and their complexes (grant no. 2021YFC2300303), CNY 3,770,000, 01/01/2021-12/31/2024 (PI)

3. National Key R&D Program Key Special Project for Intergovernmental Cooperation in Science and Technology (2024YFE0198900), CNY 4000,000, 09/01/2024-08/31/2027 (PI)

Selected Peer-reviewed Publications:

1. Zhou K*#, Xue CX#, Xu T#, Shen P#, Wei S, Wyres KL, Lam MMC, Liu J, Lin H, Chen Y, Holt KE; BRICS Working Group; Xiao Y* (2023). A point mutation in recC associated with subclonal replacement of carbapenem-resistant Klebsiella pneumoniae ST11 in China. Nature Communications. 14(1):2464.

2. Zhou K, Zhou Y, Xue CX, Xu T, Chen Y, Shen P, Xiao Y* (2023). Bloodstream infections caused by Enterobacter hormaechei ST133 in China, 2010-22. Lancet Microbe. 4(1):e13.

3. Xu T, Xue CX, Huang J, Wu J, Chen R, Zhou K* (2022). Emergence of an epidemic hypervirulent clone of Enterobacter hormaechei coproducing mcr-9 and carbapenemases. Lancet Microbe. 3(7):e474-e475. 

4. Zhou K, Cattoir V, Xiao Y* (2016). Intrinsic colistin resistance. The Lancet Infectious diseases. 16(11):1227-1228.

5. Zhou K#, Tang X#, Wang L, Guo Z, Xiao S, Wang Q, Zhuo C* (2018). An Emerging Clone (ST457) of Acinetobacter baumannii Clonal Complex 92 With Enhanced Virulence and Increasing Endemicity in South China. Clinical infectious diseases. 67(suppl_2):S179-S188.

The full list of publications can be found at //scholar.google.com/citations?user=LQvqKR4AAAAJ&hl=zh-CN